Covid may lead to diabetes: the Italian-American study in "Nature Metabolism"
Published in the journal “Nature Metabolism” and developed by Ospedale Sacco, Ospedale San Paolo and the University of Milan with an international team that includes the University of Pisa and Harvard Medical School among its partners
Diabetes and prediabetes may be some of the long-term consequences of Covid
The discovery comes from research published in the journal ‘Nature Metabolism’ and developed by Ospedale Sacco, Ospedale San Paolo and the University of Milan with an international team coordinated by Professor Paolo Fiorina whose partners include the University of Pisa and Harvard Medical School.
The study, which revealed how Covid 19-related diabetes develops, shows for the first time that viral infection can induce insulin resistance and thus impair normal β-cell function, alterations that can lead to persistent hyperglycaemia of varying severity even after recovery.
The University of Pisa was represented by Dr Giuseppe Daniele, researcher at the Department of Clinical and Experimental Medicine.
His work helped to demonstrate that the risk of developing insulin resistance and diabetes is closely and proportionally related to the cytokine storm that develops during Covid 19 infection and that this impairment persists even after recovery.
The role of cytokines and sub-inflammation in the genesis of insulin resistance in obesity and type 2 diabetes is a line of research already followed by Dr Giuseppe Daniele together with Professor Franco Folli and others, in studies conducted in San Antonio, Texas, USA.
This latest work published in “Nature Metabolism” – according to Professors Paolo Fiorina, Massimo Galli, Gianvincenzo Zuccotti of ASST Fatebenefratelli-Sacco and Franco Folli, ASST Santi Paolo e Carlo (all from the University of Milan) – may therefore help to investigate the mechanisms of diabetes in particularly frail patients and to develop new therapeutic strategies for this disease.