Insulin: lilemo tse lekholo tsa bophelo li bolokiloe
Ho sibolloa ho ileng ha fetola phekolo ea lefu la tsoekere
Insulin, e 'ngoe ea litšibollo tsa bohlokoa tsa bongaka tsa 20th lekholong la lilemo la, e ne e emela katleho e khōlō ntoeng ea ho loantša lefu la tsoekere. Pele e fihla, tlhahlobo ea lefu la tsoekere hangata e ne e le kahlolo ea lefu, ka tšepo e fokolang haholo bakeng sa bakuli. Sengoliloeng sena se latela nalane ea insulin, ho tloha ha e sibolloa ho isa tsoelopeleng ea sejoale-joale e ntseng e tsoela pele ho ntlafatsa bophelo ba batho ba nang le lefu la tsoekere.
Matsatsi a pele a lipatlisiso
Pale ea insulin e qala ka lipatlisiso tsa bo-ramahlale ba babeli ba Jeremane, Oskar Minkowski 'me Joseph von Mering, eo ka 1889 a ileng a sibolla karolo ea manyeme ho lefu la tsoekere. Ho sibolloa hona ho lebisitse kutloisisong ea hore manyeme a hlahisa ntho, eo hamorao e ileng ea tsejoa e le insulin, e bohlokoa bakeng sa ho laola maemo a tsoekere ea mali. Ka 1921, Frederick Banting 'me Charles Best, ea sebetsang Univesithing ea Toronto, o atlehile ho arola insulin 'me a bontša phello ea eona e pholosang bophelo ho lintja tse nang le lefu la tsoekere. Ketsahalo ena ea bohlokoahali e ile ea betla tsela bakeng sa tlhahiso ea insulin bakeng sa tšebeliso ea batho, ea fetola kalafo ea lefu la tsoekere haholo.
Tlhahiso le ho iphetola ha lintho
Tšebelisano pakeng tsa Univesithi ea Toronto le Eli Lilly le Company e thusitse ho hlōla mathata a amanang le tlhahiso e kholo ea insulin, e leng se etsang hore e fumanehe ho bakuli ba lefu la tsoekere qetellong ea 1922. Tsoelo-pele ena e ile ea bontša qaleho ea nako e ncha ea phekolo ea lefu la tsoekere, e lumellang bakuli hore ba phele bophelo bo batlang bo tloaelehile. Ho theosa le lilemo, lipatlisiso li 'nile tsa tsoela pele ho fetoha, tse lebisang ho nts'etsopele ea li-recombinant insulin ea motho lilemong tsa bo-1970 le li-analogues tsa insulin, tse ntlafatsang taolo ea lefu la tsoekere le ho feta.
Ho ea ka bokamoso ba kalafo ea lefu la tsoekere
Kajeno, lipatlisiso tsa insulin li ntse li tsoela pele, ka nts'etsopele ea kapele-pele le li-insulin tse tsepamisitsoeng haholo tse tšepisang ho tsoela pele ho ntlafatsa taolo ea lefu la tsoekere. Theknoloji e kang ea manyeme a maiketsetso, e kopanyang ho hlahloba tsoekere e tsoelang pele le lipompo tsa insulin, e fetoha ntho ea sebele, e fana ka tšepo e ncha bakeng sa taolo e bonolo le e sebetsang ea lefu la tsoekere. Lintlafatso tsena, tse tšehetsoeng ke lipatlisiso tse tšehelitsoeng ka lichelete ke Setsi sa Naha sa lefu la tsoekere le mafu a amanang le ho siloa ha lijo le liphio (NIDDK), e ikemiselitse ho etsa hore kalafo ea lefu la tsoekere e se be moroalo 'me e be ea motho ka mong, ho ntlafatsa bophelo ba batho ba nang le lefu lena.
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