Ubhubhani we-coronavirus we-COVID-19 ufike njengesivunguvungu kubomi bethu sonke kunye nophando lwezenzululwazi. Amaziko okhathalelo lwezempilo azama ukuqonda imida yawo kuwo onke amanqanaba, ukusuka kulwakhiwo lwofuzo ukuyahlula unyango. Ihlala ineziphumo ezingaqhelekanga. Injalo imeko ye-chloroquine kunye ne-hydroxychloroquine.

Kwinqaku elingaphambili, sithethe ngophononongo olunokubona i-hydroxychloroquine kunye ne-chloroquine kwizigulana ze-COVID-19 isisombululo esinokubakho. Nangona kunjalo, ngoku, isifundo esitsha sithambisa okuchasene noko.

I-Hydroxychloroquine kunye ne-chloroquine kunyango lwe-COVID-19 yezigulana, isifundo kwi-Lancet

The Iziphumo zonyango zibonakala zilungile ukusebenzisa ukusebenzisa kwabo okukhulu kunye nokubonelela ngokwamkelwa koogqirha abadumileyo noososayensi. Ugqirha wezamachiza owaziwayo uSilvio Garattini kunye nochwephesha wentsholongwane uFabrizio Pregliasco bacebise ukuthintela ukuthathwa kwe-hydroxychloroquine kunye ne chloroquine, ngokutsho kwengxoxo ne-arhente yeendaba yase-Italiya u-AGI, "nangona kungekho bungqina buqinisekileyo bokuthi bazuze."

Iphephancwadi elidumileyo iLancet ligxininise esi sivakalisi sokugqibela, sikhumbuza ezinye iingxelo malunga nokusebenza kwe-chloroquine kunye nehydroxychloroquine. Phambi kokuba siqhubeke, singathanda ukukhumbuza ukuba sibhekisa kuphononongo oluqhutywa nzulu kwaye lwapapashwa kwijenali eyaziwayo, eyinxalenye yamawaka ezifundo ezenziwa ngokulinganayo. Ke, akukho alamu, kodwa inkathalo kunye nokufunda ngenjongo: hlala uzolile kwaye usebenzise ii-PPEs.

 

I-Hydroxychloroquine kunye ne-chloroquine kwizigulana ze-COVID-19: indlela yokufunda

"Ubhaliso lubandakanya idatha evela kwizibhedlele ezingama-671 kumazwekazi amathandathu-abaphandi kolu phando lwenzululwazi babhala, bebhekisa kwindlela esetyenzisiweyo -. Sifaka abaguli esibhedlele phakathi kwe-20 kaDisemba ka-2019, kunye ne-14 ka-Epreli ngo-2020, ngeziphumo ezilungileyo zeLabhoratri ye-SARS-CoV-2.

Izigulana ezifumene enye yonyango lwenzalo ngaphakathi kweeyure ezingama-48 zokuxilongwa zabandakanywa kwelinye lamaqela amane (chloroquine kuphela, chloroquine ene-macrolide, hydroxychloroquine yodwa okanye i-hydroxychloroquine ene-macrolide) kunye nezigulana ezingafumananga nanye kwezi ndlela zonyango zenza iqela elilawulayo. . "

Inani lezigulana linomdla, abantu abangama-96 amawaka abachaphazeleka yi-coronavirus kwaye banyangwa kwizibhedlele ezingama-671 kwihlabathi liphela.

Iziphumo zibonakalisa: “Izigulana ezili-14,888 zazikumaqela onyango (1868 afumana i-chloroquine, ezingama-3783 zafumana i-chloroquine nge-macrolite, ezingama-3016 zafumana i-hydroxychloroquine kwaye abangama-6221 bafumana i-hydroxychloroquine nge-macrolite) kunye nezigulana ezingama-81 144 ezazikwiqela lolawulo. Izigulana ezili-10,698 (11.1%) ziye zafela esibhedlele. "

Iqela lophando, elikhokelwa liqela elivela eBrigham nakwisibhedlele sabafazi, indawo yonyango evela School Harvard Medical School.

 

Iziphumo zesiphumo sokusetyenziswa kwe-chloroquine kunye nehydroxychloroquine kwizigulana ze-COVID-19

"Asikwazanga ukuqinisekisa isibonelelo se-hydroxychloroquine okanye chloroquine - uthi olu phando-, ukuba lusetyenziswa lodwa okanye nge-macrolite, kwiziphumo zesibhedlele ze-COVID-19.

Nganye kwezi rejimeni zamachiza zazinxulunyaniswa nokwehla kokusinda kwesibhedlele kunye nokunyuka kwamaxesha e-cyricular amalungiselelo xa isetyenziselwa unyango lwe-COVID-19 ".

Ukugwetywa kwaba baphandi koogxa bezinye izilingo kuyakhawulezisa: Ukusetyenziswa kwe-hydroxychloroquine okanye chloroquine - bathi- kwi-COVID-19 kusekwe kupapasho olubanzi lwezifundo ezincinci ezingalawulwa, eziye zacebisa ukuba ukudityaniswa kwe-hydroxychloroquine nee-macrolites.

I-Azithromycin iphumelele ngokwenene ekucaciseni ukuphindaphinda kwakhona kwentsholongwane. Ngomhla wamashumi amabini anesibhozo ku-Matshi 28, the FDA ukhuphe isigunyaziso sokusetyenziswa okungxamisekileyo ngala machiza kwizigulana kwimeko yovavanyo lwezonyango (inqaku elihambelana nalo emgceni, inqaku lomhleli), ngenxa yokuba ukufikelela kwakungekho.

Amanye amazwe, njenge China, apapashe izikhokelo ezivumela ukusetyenziswa kwe-chloroquine kwizigulana ze-COVID-19. Amazwe aliqela azigcinele amachiza kwaye ekubeni ebengonelanga: kuye kwafunyanwa iimpawu zokuvunywa, njengesifo se-autoimmune kunye nesifo samathambo.

Uhlalutyo lokujonga ngokutsha kwamadoda angama-368 aphathwa nge-COVID-19 e-United States aphakamisa iinkxalabo njengoko ukusetyenziswa kwe-hydroxychloroquine kunxulunyaniswa nomngcipheko wokufa; Nangona kunjalo, iimpawu ezisisiseko phakathi kwamaqela ahlaziyiweyo zazahlukile kwaye ukubakho komkhethe akunakukhutshwa.

Olunye uphononongo lokujonga izigulana ezili-181 ezivela eFransi zabika ukuba ukusetyenziswa kwe-hydroxychloroquine, kwithamo engama-600 mg ngosuku, akunxulunyaniswa nokuxhamla kwiklinikhi kwizibonelelo zabaguli abane-COVID-19 pneumonia.

Iziphumo zophando ngokusetyenziswa kwe-hydroxychloroquine kunye chloroquine kwizigulana ze-COVID-19

Izixhobo zethu zokuphonononga izinto ezinkulu ziye zaqaqambisa ukungabikho kwesibonelelo sekloroquine kunye ne-hydroxychloroquine kwaye sibonisa ukonzakala kwezigulana ezibhedlele nge-COVID-19. I-Chloroquine kunye ne-hydroxychloroquine zinxulunyaniswa nengxaki yentliziyo, ezibonakala ngokwandiswa kwexesha lokuphumla le-QT (ixesha elithathiweyo lokuphanziswa kwe-ventricular depolarization and repolarization).

Lo matshini ubhekisa ekuphelisweni kwendlela ye-potusum ye-hERG, eyandisa, kunye nokuphinda iphindaphindeke kunye nobungakanani bezinto ezinokwenzeka zentshukumo ye-ventricular. Phantsi kwemeko ezithile, ukuya ngaphambili depolarizations kunokubangela arrhythmias ye-ventricular.

Ubungakanani bento yokuvuselela i-arrhasmia kuvame ukubonwa kwizifundo ezinesifo sentliziyo kunye nezilonda zentliziyo kuye kwanikwa ingxelo rhoqo ngesifo se-COVID-19 esonyusa umngcipheko wokufa ngequbuliso kwentliziyo.

Kuhlalutyo lokuqala, u-Borba kunye noogxa bakhe banike ingxelo yokungaqwalaselwa kabini kwezifundo ezingaboniyo kunye nezigulana ezingama-25 ezazibhedlele zine-COVID-81 kwiziko lokhathalelo oluphezulu eBrazil.

Olu phononongo licebise ukuba idosi ephezulu ye-chloroquine ibeka ingozi yokuphepha, ngakumbi xa ithathwa kunye ne-azithromycin kunye ne-oseltamivir. "

Ngamafutshane, uphononongo oluhlalutya inani elikhulu labaguli be-COVID-19 kwaye elifuna ukubonakaliswa ngononophelo luluntu lwezenzululwazi, olubiziweyo ukuba luqinisekise okanye lukhanye ngedatha esandleni into ebhengezwe ngaba baphandi.

Ukunikezelwa koku kunyangwa okusekwe kwi-chloroquine kunye ne-hydroxychloroquine, indlela yonyango esetyenzisiweyo eluntwini lonke ixhomekeke kule ngxoxo, kwaye ke ngenxa yoko ubomi bamakhulu amawaka abantu.

 

IHydroxychloroquine kunye ne chloroquine kwizigulana ze-COVID-19:

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