Imfuza ekhuselayo ifunyenwe ngokuchasene ne-Alzheimer's
Uphononongo lweYunivesithi yase-Columbia lutyhila ijini eyehlisa umngcipheko we-Alzheimer's ukuya kuthi ga kwi-70%, ivula indlela yonyango olutsha.
UFundo lweNzululwazi olumangalisayo
Ukuphumelela okungaqhelekanga Unyango lwe-Alzheimer iye yavusa amathemba amatsha okujongana nesi sifo. Abaphandi kwiYunivesithi yase-Columbia bachonge i-gene yehlisa umngcipheko wokuphuhlisa i-Alzheimer's ukuya kuthi ga kwi-70%, ukuvula iindlela ezintsha zonyango ekujoliswe kuzo.
Indima ebalulekileyo yeFibronectin
Uhlobo olukhuselayo lwemfuzo lufumaneka kwijeni elivelisayo i-fibronectin, inxalenye ephambili yomqobo wegazi-ubuchopho. Oku kuxhasa ingqikelelo yokuba imithambo yegazi yobuchopho idlala indima ebalulekileyo kwi-Alzheimer's pathogenesis kwaye inokuba yimfuneko kunyango olutsha. I-Fibronectin, idla ngokufumaneka kwimiyinge emincinci isithintelo segazi-nengqondo, ibonakala yenza impembelelo yokukhusela kwi-Alzheimer's ukuthintela ukuqokelelana okugqithisileyo kwale proteni kwi-membrane.
Amathuba oNyango athembisayo
Ngoku ka Caghan Kizil, inkokeli edibeneyo yophando, oku kufunyaniswa kunokukhokelela ekuphuhlisweni kweendlela ezintsha zonyango ezifanisa umphumo wokukhusela we-gene. Injongo iya kuba kukuthintela okanye ukunyanga i-Alzheimer's ngokusebenzisa isakhono se-fibronectin sokususa i-toxins kwingqondo ngokusebenzisa umqobo wegazi-ubuchopho. Lo mbono mtsha wonyango unika ithemba elibambekayo kwizigidi zabantu abachatshazelwe sesi sifo se-neurodeergenerative.
URichard Mayeux, inkokeli ekunye nolu hlolisiso, ivakalisa ukuba nethemba ngekamva. Izifundo kwiimodeli zezilwanyana ziqinisekisile ukusebenza kwe-fibronectin ekujoliswe kuyo unyango ekuphuculeni i-Alzheimer's. Ezi ziphumo zivula indlela yonyango ekujoliswe kulo olunokuthi lube nokhuselo oluluqilima kwisi sifo. Ukongezelela, ukuchongwa kolu luhlu lokukhusela kunokukhokelela ekuqondeni ngcono iindlela ezisisiseko ze-Alzheimer kunye nokukhusela kwayo.
Yintoni i-Alzheimer's
I-Alzheimer's sisifo esinganyangekiyo sokuwohloka kwenkqubo yemithambo-luvo ebandakanya ukuhla okuqhubelekayo kubuchule bokuqonda, inkumbulo, kunye nengqiqo.. Lolona hlobo luxhaphakileyo lwesifo sengqondo esixhalabisayo, esichaphazela ikakhulu abantu abadala, nangona sinokubonakala nakubudala obuncinane ngokwentelekiso kwiimeko ezizodwa. Uphawu lwe-Alzheimer's bubukho be-amyloid plaques kunye ne-tau protein tangles kwingqondo, ebangela umonakalo kunye nokutshatyalaliswa kweeseli ze-nerve. Oku kubangela iimpawu ezifana nokulahlekelwa yinkumbulo, ukudideka kwengqondo, ubunzima kwintetho kunye nokulungelelanisa ingcamango, kunye neengxaki zokuziphatha kunye neemvakalelo. Okwangoku, akukho nyango luqinisekileyo lwesi sifo, kodwa iinzame zophando ziyaqhubeka ukufuna unyango olutsha olujolise ekucutheni ukuqhubeka kwesi sifo kunye nokuphucula umgangatho wobomi bezigulana. Ukufunyaniswa kolu tshintsho lukhuselayo kwenza inyathelo elibalulekileyo lokulwa le meko ibuhlungu.
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