Kafukufuku wa University of Columbia akuwonetsa jini yomwe imachepetsa chiopsezo cha Alzheimer's mpaka 70%, ndikutsegulira njira zochiritsira zatsopano.

Kutulukira Kwapadera Kwasayansi

Kupambana kodabwitsa mkati Chithandizo cha Alzheimer's zadzetsa chiyembekezo chatsopano chothana ndi matendawa. Ofufuza ku Columbia University apeza jini yomwe amachepetsa chiopsezo chokhala ndi Alzheimer's mpaka 70%, kutsegulira njira zatsopano zochiritsira zomwe zingafunike.

Udindo Wofunikira wa Fibronectin

Kusiyanasiyana kwa majini oteteza kumakhala mu jini yomwe imapanga fibronectin, chigawo chachikulu cha chotchinga cha magazi ndi ubongo. Izi zimathandizira lingaliro loti mitsempha ya muubongo imakhala ndi gawo lofunikira mu Alzheimer's pathogenesis ndipo ikhoza kukhala yofunikira pamankhwala atsopano. Fibronectin, yomwe imakhalapo pang'onopang'ono m'thupi chotchinga magazi ndi ubongo, akuwoneka kuti ali ndi mphamvu zoteteza ku Alzheimer's by kuletsa kudzikundikira kwambiri kwa mapuloteniwa mu nembanemba.

Kulonjeza Kwachirengedwe

Malinga ndi Caghan Kizil, wotsogolera kafukufukuyu, zomwe apezazi zingapangitse kuti pakhale njira zochiritsira zatsopano zomwe zimatsanzira chitetezo cha jini. Cholinga chingakhale kupewa kapena kuchiza matenda a Alzheimer's pogwiritsa ntchito fibronectin kuchotsa poizoni muubongo kudzera mu chotchinga chamagazi ndi ubongo. Malingaliro atsopano achirengedwewa amapereka chiyembekezo chenicheni kwa mamiliyoni a anthu omwe akhudzidwa ndi matenda a neurodegenerative.

Richard Mayeux, wotsogolera nawo kafukufukuyu, akusonyeza kuti akuyembekezera zinthu zabwino m’tsogolo. Kafukufuku wokhudzana ndi zinyama atsimikizira mphamvu ya chithandizo cha fibronectin pakuwongolera Alzheimer's. Zotsatirazi zimatsegula njira ya chithandizo chomwe chingathe kutsata chomwe chingapereke chitetezo champhamvu ku matendawa. Kuphatikiza apo, kuzindikirika kwa mitundu yoteteza iyi kungapangitse kumvetsetsa bwino njira zomwe zimayambitsa matenda a Alzheimer's komanso kupewa kwake.

Kodi Alzheimer's ndi chiyani

Alzheimer's ndi matenda osokonekera apakati amitsempha omwe amakhudza kuchepa pang'onopang'ono kwa kuzindikira, kukumbukira, ndi luso loganiza bwino.. Uwu ndi mtundu wofala kwambiri wa dementia, womwe umakhudza kwambiri anthu okalamba, ngakhale ukhoza kuwonekeranso akadali achichepere munthawi zapadera. Chizindikiro cha Alzheimer's chili pamaso pa amyloid plaques ndi tau protein tangles muubongo, zomwe zimawononga ndikuwononga ma cell a minyewa. Izi zimabweretsa zizindikiro monga kukumbukira kukumbukira, kusokonezeka maganizo, kuvutika kwa kulankhula ndi kuganiza bwino, komanso mavuto a khalidwe ndi maganizo. Pakali pano, palibe chithandizo chotsimikizirika cha matendawa, koma kafukufuku akupitiriza kufunafuna chithandizo chatsopano chomwe cholinga chake ndi kuchepetsa kupitirira kwa matendawa ndi kupititsa patsogolo moyo wa odwala. Kupezeka kwa mtundu wotetezawu kumapanga gawo lalikulu polimbana ndi vutoli.

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