Ucwaningo lweNyuvesi yase-Columbia luveza isakhi sofuzo esinciphisa ingozi ye-Alzheimer's kuze kufike ku-70%, okuvula indlela yezindlela zokwelapha ezintsha.

Ukutholwa Kwesayensi Okumangalisayo

Ukuphumelela okungajwayelekile Ukwelashwa kwe-Alzheimer sekuvuse amathemba amasha okubhekana nalesi sifo. Abacwaningi base-Columbia University bathole isakhi sofuzo kunciphisa ingozi yokuthola i-Alzheimer's kuze kufike ku-70%, evula izindlela zokwelapha ezihlosiwe ezingase zibe khona.

Indima Ebalulekile Ye-Fibronectin

Ukuhluka kwezakhi zofuzo ezivikelayo kutholakala esakhiweni esikhiqizayo i-fibronectin, ingxenye eyinhloko yomgoqo wegazi nobuchopho. Lokhu kusekela umbono wokuthi imithambo yegazi yobuchopho idlala indima ebalulekile ku-Alzheimer's pathogenesis futhi ingabaluleka ekwelashweni okusha. I-Fibronectin, ngokuvamile ikhona ngamanani alinganiselwe ku- umgoqo wegazi-ubuchopho, kubonakala kunomphumela ovikelayo ku-Alzheimer's by ukuvimbela ukunqwabelana ngokweqile kwaleli phrotheni kulwelwesi.

Amathemba Okwelapha Athembisayo

Ngokuvumelana ne Caghan Kizil, umholi ohlanganyele wocwaningo, lokhu kutholakala kungaholela ekwakhiweni kwezindlela zokwelapha ezintsha ezilingisa umphumela wokuvikela wesakhi sofuzo. Umgomo kungaba ukuvimbela noma ukwelapha i-Alzheimer's ngokusebenzisa amandla e-fibronectin okukhipha ubuthi ebuchosheni ngomgoqo wegazi nobuchopho. Lo mbono omusha wokwelapha unikeza ithemba eliqinisekile ezigidini zabantu abathintwe yilesi sifo se-neurodegenerative.

Richard Mayeux, umholi okanye naye walolu cwaningo, uzwakalisa ithemba ngamathemba esikhathi esizayo. Ucwaningo lwamamodeli ezilwane luqinisekise ukusebenza kahle kokwelashwa okuhlosiwe kwe-fibronectin ekuthuthukiseni i-Alzheimer's. Le miphumela ivula indlela yokwelashwa okuhlosiwe okungaba khona okunganikeza ukuzivikela okuqinile kulesi sifo. Ukwengeza, ukuhlonzwa kwalokhu kwehluka kokuvikela kungaholela ekuqondeni kangcono izindlela eziyisisekelo ze-Alzheimer's kanye nokuvimbela kwayo.

Yini i-Alzheimer's

I-Alzheimer's iwukuphazamiseka okungapheli okuwohlokayo kwesimiso sezinzwa esiyinhloko esibandakanya ukwehla okuqhubekayo kwamakhono okuqonda, inkumbulo, namandla anengqondo.. Kuwuhlobo oluvame kakhulu lokuwohloka komqondo, oluthinta kakhulu abantu asebekhulile, nakuba lungase lubonakale nasebancane uma kuqhathaniswa ezimeni ezingavamile. Uphawu oluphawulekayo lwe-Alzheimer's lusebukhona be-amyloid plaque kanye nama-tau protein tangles ebuchosheni, okubangela ukulimala nokucekelwa phansi kwamangqamuzana ezinzwa. Lokhu kubangela izimpawu ezinjengokulahlekelwa inkumbulo, ukudideka kwengqondo, ubunzima ekukhulumeni nasekuhleleni imicabango, kanye nezinkinga zokuziphatha nezingokomzwelo. Njengamanje, alikho ikhambi eliqinisekile lalesi sifo, kodwa imizamo yocwaningo iyaqhubeka nokufuna izindlela zokwelapha ezintsha ezihloselwe ukwehlisa ukuqhubeka kwesimo nokwenza ngcono izinga lempilo yeziguli. Ngakho ukutholakala kwalokhu okuhlukile kokuvikela kwenza isinyathelo esibalulekile sokulwa nalesi simo esibhubhisayo.

Imithombo

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