Ubhubhane lwe-COVID-19 coronavirus selufikile njengesivunguvungu ezimpilweni zethu sonke futhi ocwaningweni lwesayensi. Izikhungo zosizo lwezempilo zizama ukuqonda imingcele yalo kuwo wonke amazinga, ukusuka esakhiweni sofuzo kuya ngokuhlukile ekwelashweni. Imvamisa kuba nemiphumela engajwayelekile. Lokhu kunjalo nge-chloroquine ne-hydroxychloroquine.

Esihlokweni esedlule, sikhulume ocwaningweni olungabona i-hydroxychloroquine ne-chloroquine ezigulini ze-COVID-19 ezingaba yisixazululo. Kodwa-ke, manje, isifundo esisha sibonisa okuphambene nalokho.

I-Hydroxychloroquine ne-chloroquine ekwelashweni kweziguli ze-COVID-19, ucwaningo ku-The Lancet

The imiphumela yokwelashwa ibonakala imihle kakhulu ukusebenzisa ukusetshenziswa kwabo okukhulu kanye nokuhlinzekela ukuvunyelwa ngabodokotela abavelele nososayensi. Isazi semithi esidumile samakhemikhali uSilvio Garattini nodokotela onguFabrizio Pregliasco batusa ukuthi kunqandwe inqubo yokuvimbela i-hydroxychloroquine ne-chloroquine, ngokusho kwengxoxo nenhlangano yezindaba yase-Italy i-AGI, "yize kungekho bufakazi obuqine bokuthi bazuzile."

Umagazini ohlonishwayo i-Lancet uqokomise lo musho wokugcina, ukhumbuza eminye imibiko ngokusebenza kahle kwe-chloroquine ne-hydroxychloroquine. Ngaphambi kokuqhubeka, sithanda ukukhumbuza ukuthi sibhekise ocwaningweni olwenziwe ngokucophelela futhi lwashicilelwa kumagazini ohlonishwayo, oyingxenye yezinkulungwane zezifundo ezenziwa ngokulinganayo ngokulinganayo. Ngakho-ke, awekho ama-alamu, kepha ukuqaphela nokufunda ngenhloso: hlala uzolile futhi usebenzise ama-PPE.

 

I-Hydroxychloroquine ne-chloroquine ezigulini ze-COVID-19: indlela yokufunda

"Lerejista ibandakanya imininingwane ephuma ezibhedlela ezingama-671 emazwenikazi ayisithupha - abacwaningi balolu cwaningo lwesayensi babhala, bebhekisa kwindlela esetshenzisiwe -. Sifaka neziguli ezisezibhedlela phakathi kukaDisemba 20, 2019, no-Ephreli 14, 2020, kwaba nemiphumela emihle yelebhu yaseSARS-CoV-2.

Iziguli ezithole enye yezindlela zokwelapha ezithakazelayo kungakapheli amahora angama-48 zokuxilongwa zifakwe kwelinye lamaqembu amane (i-chloroquine kuphela, i-chloroquine ene-macrolide, i-hydroxychloroquine kuphela noma i-hydroxychloroquine ene-macrolide) kanye neziguli ezingatholanga nalunye lwalezi zindlela zokwelapha zakha iqembu elilawulayo . ”

Isibalo seziguli siyamangaza, abantu abayizinkulungwane ezingama-96 abathintwe yi-coronavirus futhi belashwa ezibhedlela ezingama-671 emhlabeni jikelele.

Imiphumela ikhombisa: "Iziguli eziyi-14,888 1868 zaziseqenjini lokwelashwa (3783 zathola i-chloroquine, ezingama-3016 zathola i-chloroquine nge-macrolite, ezingama-6221 zathola i-hydroxychloroquine kwathi abangu-81 bathola i-hydroxychloroquine nge-macrolite) kanti iziguli ezingama-144 10,698 zaziseqenjini elilawulayo. Iziguli eziyi-11.1 XNUMX (XNUMX%) zishonele esibhedlela. ”

Iqembu labacwaningi, eliholwa yiqembu elivela eBrigham naseSibhedlela Sabesifazane, isikhungo sezokwelapha esivela WaseHarvard Medical School.

 

Imiphumela yezifundo ngokusetshenziswa kwe-chloroquine ne-hydroxychloroquine ezigulini ze-COVID-19

"Asikwazanga ukuqinisekisa inzuzo ye-hydroxychloroquine noma chloroquine - kusho lolu cwaningo -, uma lusetshenziswa lodwa noma nge-macrolite, emiphumeleni yesibhedlela ye-COVID-19.

Elinye lalawa marejimu wezidakamizwa ahlotshaniswa nokwehla kokusinda kwesibhedlela kanye nokwanda kwemvamisa ye-cyricular yingakhob lapho isetshenziselwa ukwelashwa kwe-COVID-19 “.

Isahlulelo salaba bacwaningi kozakwabo bokunye ukuhlolwa siyamangaza: "Ukusetshenziswa kwe-hydroxychloroquine noma i-chloroquine - bathi - ku-COVID-19 kuncike ekushicilelweni okusabalele kwezifundo ezincane ezingalawulwa, eziveze ukuthi ukuhlanganiswa kwe-hydroxychloroquine nama-macrolites.

I-Azithromycin iphumelele ngempela ekucaciseni ukuphindaphindwa kwegciwane. NgoMashi 28, 2020, the FDA ukhiphe ukugunyazwa kokusetshenziswa okuphuthumayo kwalezi zidakamizwa ezigulini uma kwenziwa izivivinyo zomtholampilo (i-athikili ehlobene kulayini, inothi yomhleli), inikezwe ukuthi ukufinyelela kwakungekho.

Amanye amazwe, njenge China, ashicilele imihlahlandlela evumela ukusetshenziswa kwe-chloroquine ezigulini ze-COVID-19. Amazwe amaningana agcina le mishanguzo futhi njengoba ayenele: izinkomba zitholakele zokuvunywa, njengesifo se-autoimmune kanye ne-rheumatoid arthritis.

Ukubuyekezwa kokubuka kabusha kwabesilisa abangama-368 abaphathwe nge-COVID-19 e-United States kwaveza ukukhathazeka njengoba ukusetshenziswa kwe-hydroxychloroquine kuhlotshaniswa nengozi yokufa; kodwa-ke, izimfanelo eziyisisekelo phakathi kwamaqembu ahlaziywe zazingafani futhi kungenzeka ukuthi ukukhetha kube ngaphandle.

Olunye ucwaningo lokubheka kweziguli eziyi-181 oluvela eFrance lubike ukuthi ukusetshenziswa kwe-hydroxychloroquine, ngomthamo wama-600 mg ngosuku, akuhlangene nomhlomulo weklinikhi ongalinganiswa ezigulini ezine-pneumonia ye-COVID-19.

Imiphumela yocwaningo isetshenziswa ngokusetshenziswa kwe-hydroxychloroquine ne-chloroquine ezigulini ze-COVID-19

Izinsiza-kusebenza zethu zokuhlaziya ezinkulu ziveze ukungabikhona kwenzuzo yomtholampilo ye-chloroquine ne-hydroxychloroquine futhi zikhomba umonakalo ongaba khona ezigulini ezibhedlela nge-COVID-19. I-Chloroquine ne-hydroxychloroquine kuhlotshaniswa nokukhathazeka ngethoni yentliziyo, ebonakala ngokwandisa isikhathi sokuphumula se-QT (isikhathi esithathiwe sokudonswa kwenhliziyo nokuphindeka).

Le ndlela ibhekisa ekuvinjelweni kwesiteshi se-potassium se-hERG, esikhulayo, kanye nokuphindaphinda okwenziwe ngobungcweti kanye nobude bezikhathi zamandla we-ventricular isenzo. Ngaphansi kwezimo ezithile, ukuthunyelwa kwangemva kokuqala kungadala i-arrhythmias yamasistimu.

Lokhu kuhambelana kokucunula kwe-arrhythmia kuvame ukubonakala kakhulu ezifundweni ezinesifo senhliziyo kanye nezilonda zenhliziyo kuye kwabikwa ngokuvama okuphezulu ngesikhathi sesifo se-COVID-19 esandisa ingozi yokufa kwenhliziyo kungazelelwe.

Ekuhlaziyeni okwenziwe okokuqala, uBorba kanye nozakwabo25 babike ukuthi kwenziwa ucwaningo olungaboni ngasikhathi sinye neziguli ezingama-81 ezalaliswa esibhedlela ezine-COVID-19 esibhedlela esinakekela izingane ezikhungweni zemfundo ephakeme eBrazil.

Lolu cwaningo luhlongoze ukuthi umthamo we-chloroquine ophezulu ubanga ingozi yezokuphepha, ikakhulukazi uma uthathwa ngokufana ne-azithromycin ne-oseltamivir. ”

Ngamafuphi, ucwaningo olucubungula izethameli eziningi zeziguli ze-COVID-19 futhi ezidinga ukukhonjiswa ngokucophelela ngumphakathi wesayensi, obizelwe ukuqinisekisa noma ukuphika ngemininingwane esesandleni okutholwe yilaba bacwaningi.

Ngokunikwa lokhu kudambiswa kokwelashwa okusekelwe ku-chloroquine ne-hydroxychloroquine, indlela yokwelapha esetshenziswa kubo bonke abantu incike kule mpikiswano, futhi ngenxa yalokho impilo yamakhulu ezinkulungwane zabantu.

 

IHydroxychloroquine ne-chloroquine ezigulini ze-COVID-19:

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