Emasontweni ambalwa manje, odokotela bezingane nochwepheshe besayensi bebelokhu bebheka ukuxhumana phakathi kwe-Kawasaki syndrome kanye nokwanda kokutheleleka kwezifo ze-COVID-19 ezinganeni. Manje, futhi i-Istituto Superiore Sanità (ISS) ikhombisile ukukhathazeka kwayo futhi ithatha isikhundla esicacile ngalesi sihloko.

Ingabe kukhona ukuxhumana phakathi kwe-Kawasaki syndrome ne-COVID-19 ezinganeni? Manje, ne-Istituto Superiore di Sanità (ISS) ithatha isikhundla esicacile ngalesi sihloko, ngenothi elisemthethweni.

I-Kawasaki syndrome ne-COVID-19 ezinganeni: sikhona isixhumanisi ngempela?

Umbuzo osisekelo ngukuthi: ingabe kukhona ukuxhumana phakathi kwe-Kawasaki syndrome, noma i-acute multisystem immune syndrome, kanye ne-positivity ye-COVID-19? Isifo i-Kawasaki yisifo esingahlasela abasakhulayo nezingane ezifika eminyakeni yobudala. Ezinye izincwadi zakamuva zesayensi zibonakala ziveza isixhumanisi esibonakalayo.

Ngokwezinkomba ze-European Center for Disease Prevention and Control (ECDC, isixhumanisi sewebhusayithi esemthethweni esekupheleni kwendatshana) kanye ne-World Health Organisation (WHO), wumtholampilo osefomini odinga ukuhlukaniswa yisifo seKawasaki futhi isachazeka.

Mayelana nalokhu, i-ISS ishicilele i-COVID-19 REPORT "Izinkomba zesifo seKawasaki kanye ne-acute multisystem immune syndrome ezinganeni kanye nasentsheni esimweni esiphuthumayo samanje sokutheleleka kwe-SARS-CoV-2" (isixhumanisi sombhalo ogcwele osemthethweni ekugcineni we-athikili). Umbiko ophelele uku-inthanethi futhi owomphakathi.

“Yisimo esibi kakhulu, kwesinye isikhathi esingajwayelekile esidinga ukunakwa ngudokotela wezingane, ongoti bezifo ezithathelwanayo, izazi zamathambo, odokotela bezinhliziyo nabanye ochwepheshe bezempilo, ikakhulukazi uma kubhekwa ukuhlangana nesifo i-COVID-19 esisaqhubeka. Kubalulekile ukukhomba iziguli kusenesikhathi, uzifake ezibhedlela ngokushesha futhi wenze ukuhlolwa okunembile kokuzihlola ukuze uzithumele ekwelashweni okufanele ”, kuqinisekisa uDomenica Taruscio, uMqondisi weSikhungo Sikazwelonke Sezifo Ezingavamile ze-ISS nomxhumanisi we" COVID-19 kanye neqembu elisebenzayo lezifo Ezingajwayelekile ”.

 

I-Acute multisystem inflammatory syndrome ezinganeni: ukuxhumana phakathi kwe-Kawasaki syndrome ne-COVID-19

I-ECDC ishicilele iRapid Risk Assessment mayelana nokulimazeka kwengane kanye nokutheleleka kwabakwaSARS-CoV-2 ngomhlaka 15 Meyi 2020. Kuleyo ndawo, sithola amacala asolwayo angama-230 abikwa e-European Union nase-United Kingdom, ngokushona kwababili. Isixhumanisi sisekupheleni kombhalo, phakathi kwemithombo.

Labo abathintekile baneminyaka yobudala ephakathi kweminyaka engu-7-8, kuze kube yiminyaka eyi-16. Bethule ngokubandakanyeka okukhulu kwezinhlelo eziningi, kwesinye isikhathi kudinga ukunakekelwa okunamandla. Inani langempela lalezi zifundo lisacutshungulwa, kanye nokuhlukaniswa okuqondile kwesimo salesi sifo, okwamanje okubizwa nge- “multisystem acute syndrome”

Lezi zimpawu ze-syndrome zibandakanya impendulo yokuvuvukala okungahambi kahle, ngomkhuhlane ophakeme, ukushaqeka kanye nokubandakanyeka okuxhaphakile kwe-myocardial kanye / noma i-gastrointestinal. Izinketho zokunakekelwa zifaka ama-immunoglobulins, ama-steroid, izidakamizwa ezilwa ne-cytokine. Lo mbhalo uqokomisa ukuthi njengamanje, noma kungekho encazelweni yecala elabiwe emazingeni aseYurophu, ukuxhumana phakathi kwegciwane le-COVID-19 nokuqala kwesifo kuyaqondakala, noma ngabe kunobufakazi obunqunyelwe besixhumanisi sokuqamba.

 

I-COVID-19 ne-Kawasaki syndrome, sikhona isixhumanisi? Funda ngokucophelela izifundo ezingezansi:

I-China yenze ucwaningo olushicilelwe ku- "Pediatrics" ezinganeni ezingama-2135. Lezi zingane zitholwe noma kusolakala ukuthi zinenkinga yokutheleleka kwe-COVID-19, zabikwa eChinese Center for Disease Control and Prevention phakathi konyaka we-16 kuJanuwari kanye no-8 kuFebhuwari 2020. I-112 (5.2%) yamacala okuhlolwa yakha uhlobo olunamandla lwalesi sifo ngokuqala ngokushesha kwe-dyspnoea, i-hypoxia, umkhuhlane, ukukhwehlela nezimpawu zesisu, kubandakanya nohudo.

Ezinye izingane eziyi-13 (0.6%) zazigula kakhulu futhi ngokushesha zaphathwa kabi ukucindezeleka kokuphefumula noma isifo sokuhluleka kokuphefumula; kulezi zimo, baye babika ukushaqeka, i-encephalopathy, ukulimala kwe-myocardial noma ukuhluleka kwenhliziyo, i-coagulopathy kanye nokulimala okukhulu kwezinso.

Ngo-Ephreli 2020, iwebhusayithi esemthethweni ye-US Centers for Disease Control and Prevention (CDC) yashicilela i-Morbidity and Mortality Weekly Report, lapho kwahlaziywa khona amacala ayi-149,760 ku-COVID-19. Phakathi kwawo, amacala ayi-2,572 (1, 7%) ayengaphansi kweminyaka engu-18 ubudala phakathi kukaFebhuwari 12 no-Ephreli 2.

Ezingama-73% zezingane ezinhle ze-SARS-CoV-2, okungenani eyodwa yezimpawu zomtholampilo ezazisola izinsolo zokuxilonga (umkhuhlane, ukukhwehlela kanye ne-dyspnoea) bezikhona, ngenkathi kubantu abadala leli phesenti lalingu-93%. Lowo mbhalo ubike inani lokulaliswa esibhedlela okulinganiselwa phakathi kuka-5.7% no-20%, kanye nezinga lokwamukelwa e-ICU ebangeni eliphakathi kuka-0.6% no-2%.

Izinga lokulaliswa esibhedlela beliphezulu kakhulu ezinganeni ezingaphansi konyaka owodwa (isilinganiso esilinganisiwe esingu-15% -62%) kanti eqenjini elineminyaka yobudala ephezulu ibanga elilinganisiwe lalingu-4.1-14%. Cishe ama-77% (amacala angama-28 kwangu-37) eziguli ezibhedlela zine-pathologies eyodwa noma eziningi ezihlobene, kuyilapho kweziguli ezisele ezingama-258 ezingadingi ukulala, ezingama-30 (12%) zazo zinezinye izifo.

 

Isixhumanisi esiphakathi kwe-COVID-19 ne-Kawasaki syndrome: Idatha yase-Italy kanye nesifundo eSpain

Istituto Superiore di Sanità (ilinki ye-ISS esekupheleni kwendatshana) ibike ukuthi e-Italy, kuze kube uMeyi 14, 2020, phakathi kwabashonile abangama-29,692 19 abahlekile kusukela ekuthelelekeni kwe-COVID-3, amacala amathathu avela eminyakeni engu-0 kuye kwayi-19 atholakala.

Ocwaningweni olwenziwe icala, olushicilelwe ku- “Jama Pediatrics”, ezigulini ezingama-41 zabantwana baseSpain abanegciwane eliqinisekisiwe le-COVID-19, ezingama-60% (izingane ezingama-25) zidinga ukulaliswa esibhedlela. Amacala amane awo angeniswe esibhedlela ekunakekelweni okuphezulu kanti amanye ama-4 abedingeka angena umoya omncane.

Ngokombiko we-European Surveillance System kaMeyi 13, 2020, izingane zibonisa inani eliphansi kakhulu lamacala ayi-193,351 19 e-COVID-0 aqinisekiswa e-Italy; ebangeni eliphakathi kweminyaka engama-10 ukuya kwengama-1.1, amacala abikiwe aba ngu-1% no-10% phakathi kweminyaka eyi-19 ukuya kwengama-XNUMX.

Inkomba ye-COVID-19 ye-lethity ke ilingana no-0.06% eqenjini leminyaka engu-0-15, uma iqhathaniswa ne-16.9% eqenjini labaneminyaka engaphezu kweyishumi nanhlanu.

Izingane ezi-3 ezashona e-Italy zithinteke yi-pathologies ebalulekile nebucayi (isifo se-metabolic, isifo senhliziyo, umdlavuza). Eqenjini lezingane eziyi-100 eline-Sars-CoV-2 positive swab elingene ezibhedlela zase-17 zase-Italy, zingama-52% kuphela kulezo zingane ezinomkhuhlane ezazinezimpawu ezimbili ezingahlanganiswa ne-COVID-19 (ukukhwehlela kanye ne-dyspnoea).

38% wezingane, ngokusho kocwaningo lwase-Italy olushicilelwe ku I-New England Journal of Medicine, kwakudingeka ukulaliswa esibhedlela, abangama-9 kubo babedinga ukwesekelwa ukuphefumula (6 abanezifo ezazikhona ngaphambili). Zonke lezo zingane (ngokuphelele eziyi-100) ochungechungeni zaphulukiswa. Le mininingwane ibukeka iqinisekisa kabusha ngesimo sezingane ze-COVID-19.

Kodwa-ke, kufanele banikeze ukunakekelwa okukhulu lapho izingane ezineminyaka engu-1 ubudala zibonisa izimpawu zesifo se-COVID-19. Ucwaningo olwenziwe ososayensi baseChinese nolushicilelwe eJama ngomama abakhulelwe abaneSars-CoV-2 luphenye ubudlelwane phakathi kokungavikeleki kwabesifazane nokuvikelwa kosana ekuthelelekeni, ngaphandle kokuthola imiphumela ebuhlungu.

Ukutholwa Ngakho-ke ezinganeni ezisanda kuzalwa zikamama omuhle we-SARS-CoV-2, kwezimpawu ezibonakalayo ezinjengomkhuhlane, ubunzima bokuphefumula, ukukhwehlela, izimpawu zesisu nokuthambekela kokulala, kumele kuqwashise abazali nodokotela wezingane.

 

Isixhumanisi esiphakathi kwe-COVID-19 ne-Kawasaki syndrome - FUNDA ISIHLOKO SE-ITALIAN

 

FUNDA OKWENGEZIWE

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Ingabe i-hydroxychloroquine ikhulisa ukufa kweziguli ze-COVID-19? Ucwaningo olwethulwa ku-The Lancet luxwayisa nge-arrhythmia

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IMITHOMBO

Umbiko we-ISS COVID-19

I-ISS - Izici zeSars-CoV-2 zeziguli ezifa e-Italy Report

I-ECDC - I-Pediatric inflammatory multisystem syndrome kanye nokutheleleka kwe-SARS-CoV-2 ezinganeni

 

IZINDAWO ZOLWAZI

Isikhungo saseChinese sokuLawulwa kwezifo nokuvimbela iwebhusayithi ngokusemthethweni

Iwebhusayithi esemthethweni yase-US CDC

Umbiko Wokugula Nokufa Wamasonto Onke (MMWR) we-COVID-19

Iwebhusayithi esemthethweni ye-ISS